Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Purpose
Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escalation is offered at the early circulating tumor DNA (ctDNA) molecular residual disease (MRD) detection timepoint. Ultimately, the integration of ctDNA into the clinical workflow has the potential to enhance cancer diagnosis, treatment, surveillance, and prognosis, and guide clinical decision-making in this era of personalized precision medicine.
Conditions
- Healthy Volunteer
- Prostate Cancer
- Head and Neck Cancer
- Esophageal Cancer
- Genitourinary Cancer
- Sarcoma
- Breast Cancer
- Colon Cancer
- Gastrointestinal Cancer
- Solid Tumor Cancer
- Lung Cancer
- Skin Cancer
- Melanoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Eligible healthy donors will be at least 18 years of age.
Exclusion Criteria
- Healthy donors younger than 18 years of age
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Other
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Healthy Donor Samples | - Donation of blood and/or urine samples as often as bi-monthly and as many as 24 times in total - These samples will be used to generate reference data to compare patient data to and/or to correct stereotypic noise. | |
| Samples from Repository and Banking Studies | - Healthy prostate and/or blood and/or urine samples from Genitourinary Repository - Tissue, blood, and/or drain fluid samples from Head and Neck Banking studies - Tissue and/or blood samples from Esophageal Repository - Tissue and/or blood samples from Genitourinary Repository - Tissue and/or plasma from Sarcoma Tissue Bank - Tissue and/or plasma from Breast Cancer Bank - Tissue, plasma, and/or urine from GI Tissue and Blood Bank - Tissue, blood, and/or urine from Solid Tumor Bank - Tissue, blood, and/or urine from Lung Cancer Bank - Tissue and/or blood from Skin Cancer Bank - Tissue and/or blood from Pediatric Neurosurgery Tissue Bank |
Recruiting Locations
Washington University in St. Louis and nearby locations
Washington University School of Medicine
St Louis, Missouri 63110
St Louis, Missouri 63110
More Details
- NCT ID
- NCT04354064
- Status
- Recruiting
- Sponsor
- Washington University School of Medicine