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Purpose

This study is investigating the use of a computer algorithm to analyze scans of the brain before surgery to predict how a person's tumor will respond to treatment.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Must have a radiological diagnosis of a lesion in the brain with characteristics consistent with glioblastoma multiforme. - Must be planning to undergo a pre-operative MRI. - Must be at least 18 years old. - Must be able to understand and willing to sign an IRB approved written informed consent document.

Exclusion Criteria

  • Contraindication to MRI. - Inability to have clinical follow-up (e.g., patient is out of town and will do follow-up elsewhere).

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Standard of care rsfMRI using the Support Vector Machine algorithm - Once enrolled, clinical pre-surgical MRI will be done on Siemens 3T Prisma or Skyra scanners using a standard pre-surgical tumor protocol. Resting-state functional MRI (rsfMRI) will be acquired. The Support Vector Machine (SVM) algorithm will be used on this pre-surgical MRI. - Patients will undergo post-operative MRI at approximately 8-12 weeks following surgical resection to evaluate extent of resection. Patients will then undergo subsequent MRI imaging every 2-3 months as part of routine clinical care to monitor for recurrence. The following MR sequences will be acquired: pre-and post-contrast T1-weighted, T2-weighted FLAIR, diffusion weighted imaging. MRI scans will be reviewed by a board-certified neuroradiologist to determine date of radiographic progression/recurrence. Imaging features at recurrence including location, multifocality, and presence of diffuse or distant recurrence will also be recorded.
  • Device: Support Vector Machine
    Machine learning algorithm

Recruiting Locations

Washington University in St. Louis and nearby locations

Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
Contact:
Dimitrios Mathios, M.D.
314-747-6146
mathios@wustl.edu

More Details

NCT ID
NCT05864976
Status
Recruiting
Sponsor
Washington University School of Medicine

Study Contact

Dimitrios Mathios, M.D.
314-747-6146
mathios@wustl.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.