Eligibility

Eligible Ages

Between 18 Years and 85 Years

Eligible Sex

All

Accepts Healthy Volunteers

No

Criteria

Inclusion:

- Non-specific cLBP that has persisted for at least 3 months and has resulted in pain
on at least half the days in the past 6 months.

- Age 18 - 85; the lower end of this age range was chosen to capture the growing
prevalence of young adults with cLBP, and participants over 85 years are
increasingly likely to meet one or more exclusion criteria.

- Participants report ethnic group as non-Hispanic and racial group as either
Black/African American or White/Caucasian.

Exclusion:

- Low back pain that is attributable to other factors such as ankylosing spondylitis,
infection, malignancy, compression fracture of other trauma.

- Systemic rheumatic disease/condition (e.g. rheumatoid arthritis, systemic lupus
erythematosus, fibromyalgia).

- Any other chronic pain condition that the participant believes to be more prominent
or severe than the low back pain.

- A history of clinically significant surgery to the low back within the past year.

- Uncontrolled hypertension (i.e. SBP/DBP of > 150/95), cardiovascular or peripheral
arterial disease.

- Poorly controlled diabetes (HbA1c > 8%).

- Neurological disease (e.g. Parkinson's, multiple sclerosis, epilepsy).

- Serious psychiatric disorder requiring hospitalization within the past 12 months or
characterized by active suicidal ideation.

- Diminished cognitive function that would interfere with understanding of study
procedures.