Washington University in St. Louis

Effects of Sodium-Glucose Co-transporter 2 Inhibitors on Inflammation

Purpose

The research aims to understand how a specific type of medication called Sodium-glucose co-transporter 2 (SGLT2) inhibitors affect cardiorenal inflammation.

Condition

Inflammation

Eligibility

Eligible Ages: Over 18 Years
Eligible Sex: All
Accepts Healthy Volunteers: Yes

Inclusion Criteria

Age: ≥18 - Patient has no prior history or use of Sodium-Glucose Co-transporter 2 Inhibitors. - Women who are surgically sterilized, amenorrheic for a year, on long-term contraceptives like intrauterine devices and implantable and injectable contraceptives. - Willing and able to complete the outcome assessments.

Exclusion Criteria

History of cardiac diseases (Heart Failure, NSTEMI/STEMI, cardiomyopathies, myocarditis). - Diagnosis of Type I Diabetes Mellitus. - Symptomatic hypotension (symptoms of hypotension + Systolic blood pressure < 90). - Estimated glomerular filtration rate <25 mL/minute/1.73 m2, with renal function test done within a year from the study enrollment date. - Alcohol use disorder as defined by the NIAAA or use of controlled substances or smoking cigarettes. - History of dapagliflozin or other Sodium-Glucose Co-transporter 2 Inhibitor sensitivity. - Other concomitant disease or condition that the investigator deems unsuitable for the study, including psychiatric, behavioral, or cognitive disorders, sufficient to interfere with the patient's ability to understand and comply with the study instructions or follow-up procedures. - Women who are pregnant or intend to become pregnant

Study Design

Phase: Early Phase 1
Study Type: Interventional
Allocation: N/A
Intervention Model: Single Group Assignment
Primary Purpose: Basic Science
Masking: None (Open Label)

Arm Groups

Arm	Description	Assigned Intervention
Experimental Dapagliflozin group	Participants in this arm receive dapagliflozin 10mg for three days.	Drug: Dapagliflozin (DAPA) Participants will receive 10mg of Dapagliflozin per day for three days.

Recruiting Locations

Washington University in St. Louis and nearby locations

Washington University
St Louis 4407066, Missouri 4398678 63110

Contact:
Amen Bekele Zelleke, MPH
7207612871
a.zelleke@wustl.edu

More Details

NCT ID: NCT06812429
Status: Recruiting
Sponsor: Washington University School of Medicine

Study Contact

Amen Bekele Zelleke
7207612871
a.zelleke@wustl.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.